Quote: (12-24-2018 03:49 PM)Sblazer Wrote:
Going forward my concern is the various reports as well as a scientific study, that Clomid will desensitize your pituitary from GnRH, ultimately reducing the response to producing LH. The study also claims that Nolvadex does exactly the opposite in terms of desensitization. The study can be found here: https://www.ncbi.nlm.nih.gov/m/pubmed/6781360/
I’m very interested to find out if there’s any evidence the pituitary desensitization is temporary or permanent, and if it would be a good idea to take a break from clomid, or to switch to another SERM all together.
I just read the abstract from the paper you linked.
It does not mention anything about desensitisation.
I think it's talking about how clomid increases the sensitivity of the pituitary to GnRH just like estrogen does, while tamoxifen does not.
The authors of the paper suggest that the mechanism for clomids action is more like estrogen than like tamoxifen.