[NoBalls]

I found that usually when asked this question it means that I have sucked in the interaction so far so there is really nothing to lose. I've followed the frame she set by asking this question many times and that never helps.

There is an old saying that a politician answers the question he wishes he was asked, not the question he was actually asked. I'm thinking the following may be good ways to turn the question to your advantage.

Girl: Where are your friends?
Guy: I'm looking for a cute girl who is cool. Do you know how to party?

Or

Girl: Where are your friends?
Guy: I like meeting new people who are not shallow. What are you up to tonight?

Or

Girl: Where are your friends?
Guy: I really like the music in this bar. What kind of music do you like?

Or

Girl: Where are your friends?
Guy: Do you give good blow jobs?