Scientists have recently made a breakthrough that could yield an effective birth control pill for men. This method is also distinct from RISUG which has been discussed here. I haven't read the paper yet nor do I have much expertise in the subject, but the journal that published it, Cell, is very well regarded. Will definitely read up on this most welcome of discoveries.
Maybe our resident infectious diseases expert Herr Roosh can explain it.![[Image: wink.gif]](https://rooshvforum.network/images/smilies/wink.gif)
The Smithsonian: blogs.smithsonianmag.com/science/2012/08/scientists-make-progress-towards-a-male-contraceptive-pill/
The Atlantic: m.theatlantic.com/health/archive/2012/08/a-major-advance-toward-a-birth-control-pill-for-men/261217/
Abstract: A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling during spermatogenesis. Biochemical and crystallographic studies confirm that occupancy of the lysine binding pocket by JQ1 prevents recognition of acetylated histone H4. Treatment of mice with JQ1 reduced seminiferous tubule area, testis size, and spermatozoa number and motility without affecting hormone levels. Although JQ1-treated males mate normally, inhibitory effects of JQ1 evident at the spermatocyte and round spermatid stages cause a complete and reversible contraceptive effect. These data establish a new contraceptive that can cross the blood:testis boundary and inhibit bromodomain activity during spermatogenesis, providing a lead compound targeting the male germ cell for contraception.
http://www.cell.com/abstract/S0092-8674(12)00929-4
Here is a link to the forum thread on RISUG: http://www.rooshvforum.network/thread-6904.html
Maybe our resident infectious diseases expert Herr Roosh can explain it.
The Smithsonian: blogs.smithsonianmag.com/science/2012/08/scientists-make-progress-towards-a-male-contraceptive-pill/
The Atlantic: m.theatlantic.com/health/archive/2012/08/a-major-advance-toward-a-birth-control-pill-for-men/261217/
Abstract: A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling during spermatogenesis. Biochemical and crystallographic studies confirm that occupancy of the lysine binding pocket by JQ1 prevents recognition of acetylated histone H4. Treatment of mice with JQ1 reduced seminiferous tubule area, testis size, and spermatozoa number and motility without affecting hormone levels. Although JQ1-treated males mate normally, inhibitory effects of JQ1 evident at the spermatocyte and round spermatid stages cause a complete and reversible contraceptive effect. These data establish a new contraceptive that can cross the blood:testis boundary and inhibit bromodomain activity during spermatogenesis, providing a lead compound targeting the male germ cell for contraception.
http://www.cell.com/abstract/S0092-8674(12)00929-4
Here is a link to the forum thread on RISUG: http://www.rooshvforum.network/thread-6904.html