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Science of Staying Young Forever - Google Is Now Involved

Science of Staying Young Forever - Google Is Now Involved

Honestly science is overrated; the only major discoveries in recent times have been the Human Genome Project and Hubble Space Telescope.

We can't even cure the common cold yet expect science to make us live forever; if anything "science" has just become an atheist/progressive equivalent to religion, but with Jesus' second coming and the rapture merely replaced with Ray Kurzweil inventing a cyberspace version of "heaven" where we can live forever as computer AIs.
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Science of Staying Young Forever - Google Is Now Involved

You haven't seen anything yet silver member, buckle up.

SENS Foundation - help stop age-related diseases

Quote: (05-19-2016 12:01 PM)Giovonny Wrote:  
If I talk to 100 19 year old girls, at least one of them is getting fucked!
Quote:WestIndianArchie Wrote:
Am I reacting to her? No pussy, all problems
Or
Is she reacting to me? All pussy, no problems
Reply

Science of Staying Young Forever - Google Is Now Involved

Travesty, fantastic thread you've created. I'm surprised to see so many arguing against life extension, it's very clear that it's just ego protection because they don't think that *they* will have access to this technology.

Most of the explored avenues are rejuvenative medicine, but one is surgical and only requires that we master immunosuppression effectively to conduct (which would also be a challenge necessary to overcome in very invasive transhuman/cyborg enhancement too).

The procedure is a head transplant and a surgeon is gearing up to conduct the operation next year on a man with a degenerative body disease.

Quote:Quote:

Doctors seem to be a step closer to performing a breakthrough surgery: transplanting a human head onto another body. A Russian man with a rare genetic muscle-wasting disorder has volunteered to be the first to try the procedure.

“I’m very interested in technology, and anything progressive that might change people’s lives for the better,” Valery Spiridonov from the Russian city of Vladimir, told RT.

Spiridonov, a 30-year-old qualified computer scientist, works for an IT firm. He said that his disease is getting worse every year, and usually people with Werdnig-Hoffman disorder – a disease that wastes muscles – don’t live longer than 20 years, so it would be a chance to prolong his life and help scientific research in the process. “Doing this isn’t only an excellent opportunity for me, but will also create a scientific basis for future generations, no matter what the actual outcome of the surgery is,” he said.

The operation is set to be conducted by renowned Italian surgeon Sergio Canavero, who sees the procedure as comparable to space exploration. “Russia sent Yury Gagarin into space with fair chances of dying. America sent Neil Armstrong to the moon with fair chances of dying. And the chances here are much, much better,” Canavero told RT.

According to Canavero, the operation is set to last up to 36 hours, and will cost over $11 million. Canavero has called the procedure “HEAVEN,” which is an acronym for head anastomosis venture. Anastomosis involves the surgical connecting of two parts.




During the procedure, the patient’s brain will be cooled down to 10-15 degrees Celsius (50-60 Fahrenheit) to prolong the time the cells are able to survive without oxygen.

The body will be taken from a brain-dead but otherwise healthy donor.

An ultra-sharp scalpel will be used to cut through the spinal cord, and a special biological glue will be used to connect the head to the new body.

After the operation, Valery will be put into a coma for three to four weeks to prevent any movement. He will also be given immunosuppressants with the aim to prevent the body rejecting it's head.
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Science of Staying Young Forever - Google Is Now Involved

What people dont seem to get is that the human body is DESIGNED to age and die. There are animals that dont age, we are not one of them.

It seems that the model of birth-aging-death is the one nature has selected as the best one for us.

I suppose it may be related to evolution, if you believe in such a crazy theory.
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Science of Staying Young Forever - Google Is Now Involved

^^ Okay now the stuff up there is just crazy a head transplant? I don't know if I would want to be connected to some other guy's dead body. I am a fan of just replacing dead and bad cells with new ones created from your existing genome. So it is still completely yourself. Like repainting a house.

I am very leery of all the mind upload to a computer, robot bodies, other human bodies. I would need to see the technology in action over time, even seeing that could irk me for whatever reason deep down.

I am also very distrusting of cryo freezing after you die, who knows how you could be "brought back" in what form and by what type of being that may exist in some insane future. All these I have listed are really about fear of loss of control and spirit.

If someone injects some super stem cells made from my own DNA into me that clear out my bad cells and replenish old with young ones to rebuild my tissue and blood I am cool with that. In fact athletes do this now to heal injuries all the time now on a smaller scale.

^ Yeah and we are designed to get polio, and the plague, and eaten by wolves and bears. What the fuck happened to all that? Some people are designed to get muscle atrophy disease, some are designed to be retarded.

SENS Foundation - help stop age-related diseases

Quote: (05-19-2016 12:01 PM)Giovonny Wrote:  
If I talk to 100 19 year old girls, at least one of them is getting fucked!
Quote:WestIndianArchie Wrote:
Am I reacting to her? No pussy, all problems
Or
Is she reacting to me? All pussy, no problems
Reply

Science of Staying Young Forever - Google Is Now Involved

I just have to reiterate it is mindblowing to me the mental gymnastics people pull off to not accept infectious disease as something people should naturally let happen to them.

These same people would be pro-for finding a cure to cancer.

Then they don't realize cancer is a disease of aging first and foremost. There are some from environmental factors, vast majority are from aging and make for terrible deaths.

So infectious disease BAD! Ok to cure! Aging disease... I don't like them! Fix them! Hey do it in a natural way and let me age and die, take away the bad stuff! Don't let me live until 150 like I am a 25 year old.

Still in disbelief. It is like watching people in medieval times wanting to dunk the witch to see if she floats or drowns.

SENS Foundation - help stop age-related diseases

Quote: (05-19-2016 12:01 PM)Giovonny Wrote:  
If I talk to 100 19 year old girls, at least one of them is getting fucked!
Quote:WestIndianArchie Wrote:
Am I reacting to her? No pussy, all problems
Or
Is she reacting to me? All pussy, no problems
Reply

Science of Staying Young Forever - Google Is Now Involved

Quote: (05-26-2016 01:40 AM)Travesty Wrote:  

^^ Okay now the stuff up there is just crazy a head transplant? I don't know if I would want to be connected to some other guy's dead body. I am a fan of just replacing dead and bad cells with new ones created from your existing genome. So it is still completely yourself. Like repainting a house.

I am very leery of all the mind upload to a computer, robot bodies, other human bodies. I would need to see the technology in action over time, even seeing that could irk me for whatever reason deep down.

I am also very distrusting of cryo freezing after you die, who knows how you could be "brought back" in what form and by what type of being that may exist in some insane future. All these I have listed are really about fear of loss of control and spirit.

If someone injects some super stem cells made from my own DNA into me that clear out my bad cells and replenish old with young ones to rebuild my tissue and blood I am cool with that. In fact athletes do this now to heal injuries all the time now on a smaller scale.

Agreed with all the above. Rejuvenative medicine is the ideal, but to be fair if only these other methods exist then it's better then ceasing to exist.

Quote: (05-26-2016 01:59 AM)Travesty Wrote:  

I just have to reiterate it is mindblowing to me the mental gymnastics people pull off to not accept infectious disease as something people should naturally let happen to them.

These same people would be pro-for finding a cure to cancer.

Then they don't realize cancer is a disease of aging first and foremost. There are some from environmental factors, vast majority are from aging and make for terrible deaths.

So infectious disease BAD! Ok to cure! Aging disease... I don't like them! Fix them! Hey do it in a natural way and let me age and die, take away the bad stuff! Don't let me live until 150 like I am a 25 year old.

Still in disbelief. It is like watching people in medieval times wanting to dunk the witch to see if she floats or drowns.

People don't realise that ageing itelf is not necessary. There's 7 byproducts of metabolism which accumulate over time which comprise ageing itself.

We've got potential treatments for those 7 byproducts, now we've just got to implement them.

I think people still view ageing as essential because they don't understand what ageing actually is.

It's like if we didn't have scissors to cut our hair so it instead proceeded to grow indefinitely. Then when scissors comes along people can't fathom that we can actually get rid of the stuff.
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Science of Staying Young Forever - Google Is Now Involved

Quote: (05-26-2016 01:18 AM)Valentine Wrote:  

Most of the explored avenues are rejuvenative medicine, but one is surgical and only requires that we master immunosuppression effectively to conduct (which would also be a challenge necessary to overcome in very invasive transhuman/cyborg enhancement too).

The procedure is a head transplant and a surgeon is gearing up to conduct the operation next year on a man with a degenerative body disease.

Quote:Quote:

Doctors seem to be a step closer to performing a breakthrough surgery: transplanting a human head onto another body.

Holy shit, that's amazing! If this works, it would be the most revolutionary medical advance since, I don't know, the advent of general anesthesia. I can't even imagine what the outcome of such a procedure would be. What would be the result of transplanting an old man's head onto an elite young athlete's body? It would be truly fascinating to follow the development of this technology.

With that said, I don't understand how this is going to be remotely possible. Breaking your neck or damaging your spinal cord has always been a sentence of lifelong paralysis, and it remains so to this day. We cannot even repair damaged spinal cords, so how are they going to fuse the spinal cords of two individuals in this head transplant operation? That seems much harder than merely fixing a single point of damage in a paralyzed person.

Edit: so I read a few more articles and the spinal cord reattachment does in fact seem to be the sticking point. The surgeon proposing this operation plans to cut both spinal cords (cadaver's and recipient's) with an extremely sharp knife in order to minimize structural injury to the cords, and then hopes that when the two are glued together they will spontaneously fuse. But that part has never been done and is complete speculation. If they get any fusion at all, it will most likely end up being very marginal, probably not enough to even feel your new leg being cut off, let alone eat, run, or play sports.

I'm gonna go and say this operation is not going to happen and is just attention whoring from the Italian surgeon.
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Science of Staying Young Forever - Google Is Now Involved

This long article gives an interesting round-up of the current research focus and the challenges in the field:
The Immortality Hype: Is It Medically Possible to Live Forever?

Quote:Quote:

The Ellison Medical Foundation has spent nearly $400 million on longevity research. Oracle founder Ellison told his biographer, “Death makes me very angry.” PayPal cofounder and venture capitalist Peter Thiel helped fund the SENS Research Foundation, a longevity organization co-led by British gerontologist Aubrey de Grey, who’s argued we might someday halt aging and extend life indefinitely. (Arrison, Thiel’s longtime friend, introduced the two.)
...
The big goal of the Silicon Valley titans is not to extend longevity by beating back cancer, heart disease, Alzheimer’s disease, or any of the other diseases that most of us succumb to. Rather it’s to use molecular biology to decode the very mechanics behind the process that is the biggest single risk factor in all of these diseases—the process of aging itself—and to attempt to halt it in its tracks. In recent years, researchers have made undeniable strides in decoding the cellular processes that go awry as we age.
...
The interest of Silicon Valley and private funders has done more than that. They have helped to shift the target of research from addressing diseases associated with getting older to the core processes of aging itself. According to scientists and insiders in aging research, the ingestion of private money into the field has been a culturally disruptive force with tremendous potential benefits. And the science is here to prove it.
...
She notes that a growing body of research suggests that treatments for some chronic diseases can accelerate the onset of age-related change. As childhood cancer survivors who have been treated under the age of 14, for instance, mature into young adulthood, many of them have a profile of chronic illness—cardiovascular disease, poor bone health, strokes—that looks more like that of 50- to 70- year olds.

“The Office of Cancer Survivorship at NCI was established because survivors came back and said, ‘Hey, that’s great, I’m living longer with this disease, but what’s my life going to be like?’ ” Rowland says. “So it’s not enough to extend the length of survival, we now need to be looking at the quality of that life.”
...
The biggest reason for optimism, however, may well be the relentless march of aging itself. “I’m going to be very pragmatic, so here’s my take,” Rowland says. “Baby boomers are about to create a silver tsunami in cancer that we are unprepared for. So you bet that those of us who are boomers are going to be pushing the pipeline, putting money in aging research, because we want it all figured out before we really fall into it.”

"I'd hate myself if I had that kind of attitude, if I were that weak." - Arnold
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Science of Staying Young Forever - Google Is Now Involved

Quote: (05-26-2016 05:06 AM)Fast Eddie Wrote:  

Quote: (05-26-2016 01:18 AM)Valentine Wrote:  

Most of the explored avenues are rejuvenative medicine, but one is surgical and only requires that we master immunosuppression effectively to conduct (which would also be a challenge necessary to overcome in very invasive transhuman/cyborg enhancement too).

The procedure is a head transplant and a surgeon is gearing up to conduct the operation next year on a man with a degenerative body disease.

Quote:Quote:

Doctors seem to be a step closer to performing a breakthrough surgery: transplanting a human head onto another body.

Holy shit, that's amazing! If this works, it would be the most revolutionary medical advance since, I don't know, the advent of general anesthesia. I can't even imagine what the outcome of such a procedure would be. What would be the result of transplanting an old man's head onto an elite young athlete's body? It would be truly fascinating to follow the development of this technology.

With that said, I don't understand how this is going to be remotely possible. Breaking your neck or damaging your spinal cord has always been a sentence of lifelong paralysis, and it remains so to this day. We cannot even repair damaged spinal cords, so how are they going to fuse the spinal cords of two individuals in this head transplant operation? That seems much harder than merely fixing a single point of damage in a paralyzed person.

Edit: so I read a few more articles and the spinal cord reattachment does in fact seem to be the sticking point. The surgeon proposing this operation plans to cut both spinal cords (cadaver's and recipient's) with an extremely sharp knife in order to minimize structural injury to the cords, and then hopes that when the two are glued together they will spontaneously fuse. But that part has never been done and is complete speculation. If they get any fusion at all, it will most likely end up being very marginal, probably not enough to even feel your new leg being cut off, let alone eat, run, or play sports.

I'm gonna go and say this operation is not going to happen and is just attention whoring from the Italian surgeon.

Wouldn't the old man's head end up further decaying and dying before the young body does?
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Science of Staying Young Forever - Google Is Now Involved

It seems Google is supporting and promoting The Trans-Pacific Partnership ... [Image: sad.gif]

http://publicpolicy.googleblog.com/2016/...-step.html
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Science of Staying Young Forever - Google Is Now Involved

So some big progress was made by SENS (Aubrey De Grey's organization).

2 of the 13 protein coding genes from mitochondrial DNA simultaneously functioning in a cell line.

What this means I think is that out of the 13 now they can replace 2 of the protein coding genes which will negate the negative effects of mitochondrial mutations, one of the largest causes of aging. If you can get at 13, now you can replace everything in a maintenance mode and no longer suffer from mutations.

Once you solve a pair to work together it is just a matter of time before they get all 13 to work together.

Everyone else in the research community gave up on this simple idea to replace mutations with back up copies, because they are retards.

It was SENS's first funded project by Peter Thiel 7 years ago. Thank God for Peter Thiel, a Gay Angel, who also is a Trump supporter and Aubrey for being smart enough to see what works.

Yes this stuff takes time to see results, once you do it is a snowball. It is utterly possible.

I guarantee you this thread in 15 years or so will make the Trump thread look pathetic in comparison.





SENS Foundation - help stop age-related diseases

Quote: (05-19-2016 12:01 PM)Giovonny Wrote:  
If I talk to 100 19 year old girls, at least one of them is getting fucked!
Quote:WestIndianArchie Wrote:
Am I reacting to her? No pussy, all problems
Or
Is she reacting to me? All pussy, no problems
Reply

Science of Staying Young Forever - Google Is Now Involved

Didn't they do this to a cow back in the day?

"A stripper last night brought up "Rich Dad Poor Dad" when I mentioned, "Think and Grow Rich""
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Science of Staying Young Forever - Google Is Now Involved

The Economist dedicated an entire edition to this:

[Image: jkfPRcIa-z8.jpg]
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Science of Staying Young Forever - Google Is Now Involved

Looking forward to more serious efforts being directed towards fighting aging. Hopefully we can stay ahead of the curve.
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Science of Staying Young Forever - Google Is Now Involved

From The Economist :

Unless ageing is treated as an indication, anti-ageing drugs can’t get regulatory approval. And there’s little incentive to work on drugs you can’t sell.

If regulators were to change their stance, though, the interest would be immense. A condition that affects everyone is as big a potential market as can be imagined. And there are hints that the stance may indeed be changing. Two existing drugs approved for other purposes—metformin, widely used and well tolerated as a treatment for diabetes, and rapamycin, which reduces the risk of organ transplants being rejected—look to some researchers as though they might have broad anti-ageing effects not unlike those claimed for CR. In 2014 a study of 90,000 elderly patients with type 2 diabetes found that those receiving metformin had higher survival rates than matched non-diabetic controls. Other work has shown its use is associated with a decreased risk of cancer.

Scientists at the Institute for Ageing Research at the Albert Einstein College of Medicine, in New York, want to mount a trial of metformin in elderly subjects to see whether it delays various maladies (and also death). If that turns out to be the case, it will go a long way to showing that there is a generalised ageing process that can be modulated with drugs. Nir Barzilai, one of the researchers involved, says an important reason to do the trial is to have an indication against which next-generation ageing drugs can be assessed by regulators.
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Science of Staying Young Forever - Google Is Now Involved

My question is:





“As long as you are going to be thinking anyway, think big.” - Donald J. Trump

"I don't get all the women I want, I get all the women who want me." - David Lee Roth
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Science of Staying Young Forever - Google Is Now Involved

^^

And the answer is...




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Science of Staying Young Forever - Google Is Now Involved

Quote: (08-21-2016 03:03 PM)seniol Wrote:  

From The Economist :

Unless ageing is treated as an indication, anti-ageing drugs can’t get regulatory approval. And there’s little incentive to work on drugs you can’t sell.

If regulators were to change their stance, though, the interest would be immense. A condition that affects everyone is as big a potential market as can be imagined. And there are hints that the stance may indeed be changing. Two existing drugs approved for other purposes—metformin, widely used and well tolerated as a treatment for diabetes, and rapamycin, which reduces the risk of organ transplants being rejected—look to some researchers as though they might have broad anti-ageing effects not unlike those claimed for CR. In 2014 a study of 90,000 elderly patients with type 2 diabetes found that those receiving metformin had higher survival rates than matched non-diabetic controls. Other work has shown its use is associated with a decreased risk of cancer.

Scientists at the Institute for Ageing Research at the Albert Einstein College of Medicine, in New York, want to mount a trial of metformin in elderly subjects to see whether it delays various maladies (and also death). If that turns out to be the case, it will go a long way to showing that there is a generalised ageing process that can be modulated with drugs. Nir Barzilai, one of the researchers involved, says an important reason to do the trial is to have an indication against which next-generation ageing drugs can be assessed by regulators.

Under current regulations (at least in the US) approval isn't necessary in most cases unless the manufacturer makes a specific marketing claim. They can conduct trials showing life extension results and publish the findings for the niche that's interested already. Of course, there have been attacks on the right to supplement so vigilance is necessary. Although Metformin is a prescription drug it is readily available for import from overseas, from reliable sources. In cases like this a script isn't a bad idea in my opinion, because there is potential for side effects from digestive issues to organ damage. I looked into it and decided against it at this time, does anyone here take it?

Because aging and death take so long to manifest it would be difficult to make a case for regulated medication addressing it. The current system is all about treating easily measurable symptoms - someone has high blood pressure, we give them this drug, blood pressure goes down, it gets the "approved" stamp. If a company synth'd a medication to preemptively stave off certain types of cancers should everyone take it, or just those with certain genetic markers? If they synth one which ups levels of superoxide dismutase, would we need to wait around for a decade while regulators debate whether oxidation is responsible for certain aspects of aging? Most medications have side effects, which bureaucrat makes the risk:reward cutoff? If the worst should happen and we go to single-payer, who pays for all these drugs? In a sense, the current system of potential life extension supplements where those who make the effort to research them and work hard to afford them is one of natural selection's last stands in the western world.
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Science of Staying Young Forever - Google Is Now Involved

More from The Economist:

One of these, resveratrol, caused a great deal of excitement among longevity researchers a few years ago because it kept mice on rich diets youthful. A lot of the initial interest has waned since it was discovered to be less helpful in mice that are not overweight, but it is still being investigated as an Alzheimer’s treatment.

David Sinclair of the Harvard Medical School, who was part of the initial enthusiasm, says
it has a number of targets within the cell. Among them are a set of proteins known as sirtuins which appear to be activated by resveratrol. Dr Sinclair created a company, Sirtris Pharmaceuticals, to investigate the potential of drugs aimed at these targets. GSK, a British pharma company which bought Sirtris in 2008, continues this work, though to date it has not yielded as much as was once hoped.

Sirtuins may act as metabolic sensors, and a number are found exclusively in the mitochondria, the structures in cells that look after respiration and which are central to the evolving concept of cellular ageing. Thomas von Zglinicki of Newcastle University says ageing cells are characterised by mitochondrial damage and have difficulty recycling damaged or broken cell machinery. They produce pro-inflammatory factors called cytokines which move neighbouring cells to senescence; chronic progressive inflammation of this sort drives various age-related diseases.

João Passos, also at Newcastle University, says cells from which mitochondria are removed start to look more like young cells and stop secreting cytokines. Other work has shown that killing off mitochondria can mimic some of the effects of drugs that activate mitochondrial renewal—such as rapamycin. Faster turnover of mitochondria seems to improve their functioning.

Data against death

Such discoveries in cell and molecular biology have perked up commercial interest in longevity. So too has data from the hundreds of thousands of human genome sequences. Dr Zhavoronkov’s Insilico Medicine, based in Baltimore, is using machine learning on vast piles of published genomic data to work out the differences between the tissues of young and old people and to look at how patterns of gene expression evolve as people age. It then looks in drug databases for molecules that might block the effects of the genes it thinks matter.
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Science of Staying Young Forever - Google Is Now Involved

Scientists reverse ageing in mammals and predict human trials within 10 years

Quote:Quote:

An end to grey hair and crows-feet could be just 10 years away after scientists showed it is possible to reverse ageing in animals.

Using a new technique which takes adult cells back to their embryonic form, US researchers at the Salk Institute in California, showed it was possible to reverse ageing in mice, allowing the animals to not only look younger, but live for 30 per cent longer.

The technique involves stimulating four genes which are particularly active during development in the womb. It was also found to work to turn the clock back on human skin cells in the lab, making them look and behave younger.

Scientists hope to eventually create a drug which can mimic the effect of the found genes which could be taken to slow down, and even reverse the ageing process. They say it will take around 10 years to get to human trials.

"Our study shows that ageing may not have to proceed in one single direction," said Dr Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory. “With careful modulation, aging might be reversed.

"Obviously, mice are not humans and we know it will be much more complex to rejuvenate a person. But this study shows that ageing is a very dynamic and plastic process, and therefore will be more amenable to therapeutic interventions than what we previously thought."

Scientists have known for some time that the four genes, which are known collectively as the Yamanaka factors, could turn adult cells back to their stem cell state, where they can grow into any part of the body.

But it was always feared that allowing that to happen could damage organs made from the cells, and even trigger cancer.

However, it was discovered that stimulating the genes intermittently reversed ageing, without causing any damaging side effects.

In mice with a premature ageing disease, the treatment countered signs of ageing and increased their lifespan by 30 per cent. If it worked similarly in humans it could allow people to live until more than 100 years old. In healthy mice it also helped damaged organs to heal faster.

"In other studies scientists have completely reprogrammed cells all the way back to a stem-cell-like state," says co-first author Pradeep Reddy, also a Salk research associate.

"But we show, for the first time, that by expressing these factors for a short duration you can maintain the cell's identity while reversing age-associated hallmarks."

The breakthrough could also help people stay healthier for longer. The ageing population means that the risk of developing age-related diseases, such as dementia, cancer and heart disease also rises. But if the body could be kept younger for longer then it could prevent many deadly diseases for decades.

http://www.telegraph.co.uk/science/2016/...ls-within/

Pros: more young pussy, more time to bang young pussy even though you might be over 40 years old
Cons: no more MILFs

From my point of view, this is a net negative [Image: tard.gif]
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