[BlueOcean01]

I noticed some complaints about headaches. What I've found is if I drink a lot of water - 1 1/2 gallons - throughout the day I don't get the headaches on modafinil. If I don't stay well hydrated - < 1/2 gallon - then I do get them. I always believed water had no impact on it and the people who said that were simply dehydrated, but after nine months it's been the case with me.

[DJ Horton]

Yeah drink tons of water. Choline helped me as well. It's a cheap supplement, good for brain function, so whatever Modafinil does I think it strains your brain especially if you don't have the proper nutrients, and that can cause a headache.

Choline is naturally found in egg yolks, so I've also read it recommended to have a big egg breakfast when you take modafinil, but the supplement works great and it's super cheap. .09 each for the Nature's Way brand from Amazon, which is what I've used.

[Sidney Crosby]

Took one before going to the gym, did an hour of cardio another hour of intense lifting then when I got home I shovelled dirt for an hour.... talk about yuge energy and focus. I felt like I could have spent 5 hours in the gym. Woke up at 7, took the pill at about 9 and felt like Bradley Cooper till about 5pm.

Worth the couple bucks.

[MarsBlacc]

I tried it a couple of time while in Vegas and stopped because it started making my ears itch. Honestly, its really good if you want that god-like energy and clarity but I can see where you can get addicted to feeling like a god.

[Sidney Crosby]

How long do you guys notice it? I take a 200mg pill and it seems effective for roughly 8 hours.

I've never used them at night or while drinking so I wonder how that would work.

[Isaac Jordan]

It's been several months since I started eating eggs on my modafinil days and I've completely eliminated the headaches I used to have. The drug kills my appetite so I usually just drop a few eggs yolks into green teas sprinkled throughout the day. I assume it's the choline, but egg yolks are crazy good for you in a bunch of other ways so I'm going to stick with them rather than buying a supplement.

[polar]

To start off, this is not medical advice, I am not a doctor, lawyer, physician, personal trainer, or your mother.

My thoughts, as they relate to this thread:
1) if you take modafinil regularly, consider supplementing tyrosine.
2) consider taking a tyrosine supplement with modafinil. (similar to my thoughts on taking piracetam with choline which I've mentioned above.)
3) manage stress and cortisol levels through lifestyle and supplements, such as ashwagandha

A fellow forum member recommended me this link for some thoughts on adrenal fatigue:
https://www.t-nation.com/living/tip-you-...al-fatigue

I’ve quoted the most relevant content below, which is also the majority of the article. If you find these quotes relevant, read it in full.

Quote:

Here's what people generally experience when they suspect they have adrenal fatigue:
-Drop in motivation
-Low energy
-Decrease in willpower/discipline
-Anhedonia (lack of pleasure)
-Mood swings
-Disrupted sleep patterns
-Not feeling rested after a full night of sleep
-Decrease in physical and mental performance

What CAN Cause These Problems?
The most likely causes are:
1. Dopamine depletion
2. Dopaminergic receptor desensitization
3. Adrenergic receptor desensitization
4. Noradrenaline depletion
...
Dopamine and adrenaline are activating neurotransmitters. They turn on the nervous system, increasing motivation, willpower, drive, competitiveness, and physical and mental performance. They also have their own impact depending on the part of the brain they work on. For example, dopamine is the "pleasure" neurotransmitter.

Both are tightly connected because adrenaline is ultimately fabricated from dopamine. Dopamine can be converted to noradrenaline which can itself be converted into adrenaline.

So the more adrenaline you need to produce, the more dopamine you use up. If you don't produce a lot of dopamine, and you use a lot of it to produce adrenaline, you run the risk of depleting dopamine stores.
…
1. Dopamine depletion
People with low dopamine production will run the risk of depleting their dopamine when they're asking their body to pump out too much adrenaline by putting themselves in stressful situations.

2. Dopaminergic receptor desensitization

Another possibility is making the dopaminergic receptors less sensitive. In that case, the effect is similar to dopamine depletion: you have plenty of dopamine, but the receptors simply aren't responding to it.
…
It's more likely to happen to people who abuse substances/drugs that directly target the dopamine receptors. (cocaine, amphetamines, Ritalin, nicotine)
…
The other possibility, and it's much more frequent, is either adrenergic receptor desensitization or noradrenaline depletion.

3. Adrenergic Receptor Desensitization
The adrenergic receptors are the most easy to get desensitized.
…when your own adrenergic receptors become desensitized you stop responding to your own adrenaline. And that's what causes low energy, no motivation, no discipline, a drop in self-esteem, bad performance, etc.

If you're constantly under stress and pumping out adrenaline, you can easily make your receptors resistant. THIS is the most common cause of what we erroneously call "adrenal fatigue."

4. Noradrenaline Depletion
A last possibility is a depletion of noradrenaline. This can be caused by a chronic and excessive cortisol elevation. See, cortisol, on top of being an enemy for muscle growth, is what increases the conversion of noradrenaline to adrenaline. The more cortisol you produce, the more you convert noradrenaline to adrenaline.

Symptoms of noradrenaline depletion include:
-Low energy
-Lack of focus
-Problems concentrating
-Disorganization
-Low blood sugar

The take-home message? Excessive chronic cortisol levels can lead to what we think is "adrenal fatigue" by either depleting noradrenaline (easier to fix) or desensitization of the adrenergic receptors (harder to fix).

(split to differentiate the “theory” vs. “suggested solution”

Quote:

How Do You Know Which One It Is?

Besides blood tests, you need to rely mostly on behavioral observations. But there's one test that can narrow it down.

Take 7 grams of tyrosine on an empty stomach in the morning, wait 30 minutes, and assess how you feel. Compare it to how you feel normally on most mornings.

If after 30 minutes of taking tyrosine you feel awesome, much better and more energetic than normal, the problem is likely dopamine depletion (tyrosine is used to make dopamine).

If you feel good, but not to the point of feeling like you just found the magic bullet, it's likely noradrenaline depletion. In that case it might take 45 minutes to start feeling a bit better. That's because tyrosine will make dopamine which will then increase noradrenaline.

If you still feel like crap after 30-45 minutes, and there's no difference, then it's more than likely adrenergic desensitization.

The first two cases share the same basic solution: increase dopamine levels.

Here they insert a plug for their product, which is a supplement consisting of vitamin B6, B12, ALCAR, Tyrosine, Choline, DMAE, and Theanine. They also recommend combining this with a Rhodiola supplement.

Quote:

If your problem is noradrenaline depletion, you might also want to reduce cortisol levels by taking 3-5 grams of glycine and a small dose of magnesium (500 mg.) post-workout and in the evening. Glycine is a neurological inhibitor which will decrease cortisol production due to over-activation, and magnesium can dislocate the adrenaline from the adrenergic receptors.
If your problem is adrenergic desensitization, taking small doses of magnesium 3-4 times a day (500 mg.) to prevent excessive binding of adrenaline to the receptors will help. So will increasing meal frequency and carb intake.
A higher meal frequency and more frequent carb feedings will decrease adrenaline production both directly and by decreasing cortisol, which will decrease noradrenaline to adrenaline conversion.
If you're a carbo-phobe you might think, "Yeah, but I'm gonna get fat!" Maybe you'll add one or two pounds of fat in the process. But that's nothing compared to the long-term damage of keeping your receptors resistant.

As for training, all of these situations require that you decrease volume by around 40-50%, decrease frequency (do three or four weekly workouts only), increase rest intervals, and stay away from intensity techniques until the problem is solved.

TLDR:
-Simplification of neurotransmitter production pathways:
tyrosine -> dopamine -> noradrenaline (aka norepinephrine) -> adrenaline

-Red-lining your body for extended periods leads to elevated cortisol and adrenaline levels, and therefore reduced levels of dopamine

-With extended stress, you can have a breakdown in
1) dopamine levels: not enough tyrosine to produce dopamine (article recommendation: supplement tyrosine)
2) dopamine receptor sensitivity: usually due to abusing “uppers” (solution: drop the booger sugar)
3) adrenaline receptor sensitivity: overproduction of adrenaline, probably due to something like Clen. (article recommendation: 500mg of magnesium 3-4x / day, higher meal frequency, more carbs)
4) noradrenaline depletion: shortage of noradrenaline due to high cortisol levels, leading to excessive adrenaline production and low dopamine levels as a result. (article recommendation: supplement choline and magnesium; consider tyrosine; decrease cortisol levels through more regular carb intake.)
*Not medical advice*

Why this matters in context of modafinil:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696807/
"...modafinil at therapeutic doses produces elevations in brain dopamine through blockade of dopamine transporters..."

High stress = elevated cortisol = higher adrenaline production. This means conversion of dopamine to noradrenaline and then to adrenaline. As a result, dopamine levels are low, meaning modafinil will stop having an effect.

Figure out what your problem is according to the steps above, then solve it.

Other useful links:
https://universityhealthnews.com/daily/d...otivation/
To address low dopamine levels, this link recommends L-tyrosine, mucuna and L-DOPA, theanine, and rhodiola, along with your standard multivitamin (especially zinc, B6 and folate)

https://bebrainfit.com/supplements-reduce-cortisol/
Other than getting your lifestyle in check, this link recommends ashwagandha, rhodiola, ginkgo, fish oils, phosphatidylserine, and theanine. (Note: affiliate marketing site)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
This study suggests that ashwagandha supplementation (300mg 2x/days, 60 days) significantly reduced serum cortisol levels, perceived stress levels, and improved perceptions of general health (including anxiety).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328957/
Glycine supplementation improves sleep quality and improves perception of daytime sleepiness and fatigue during periods of restricted sleep

[Batman_]

I made a site that provides information on brands and valid coupon codes for Afinil Express.

https://afinilexpresscouponcode.com/

Will be continually updated with tested codes for the best discount rate available.

[Batman_]

(12-24-2017 10:23 PM)Rain97 Wrote:  

Had a look at the afinil express website 20 tablets for $56 that’s way too much. The last place I bought it from was https://www.unitedpharmacies-uk.md/Modal...p-974.html after shipping becomes just under £20 for 10 200mg pills. Why such a difference in price?

That's only available in the UK. I think it's because in some countries Modafinil is available as a generic.

[LatinoHeat]

Did Modafinal for a few months here in Mexico almost every other day as its available off the counter, never been so productive in my life, but gave me terrible mood swings, made me pissed off as fuck all the time, lost hunger and therefore muscle gains, too much negative for the positive.

In my opinion its stronger than adderall with stronger side effects.

better to have natural energy levels by keeping your T high, going to sleep early and getting a good nights rest, hitting the gym 5 days a week and having lots of good sex.

Doctors my entire life have told me I need adderall or ritalin to be succesful because of my made up fake "ADHD" disease, fuck them, don't need any of that garbage.

Any drug that has an up always has a down no matter what a psychiatrist/doctor tells you, there is no free lunch.

p.s. If you guys happen to make a trip to mexico Modafinal here is known as modiodal and available in 90%+ of pharmacys, its relatively cheap at about $2/ 200mg pill (or $1 per dose)

But take it sparingly bros trust me, it fucks you up fast, even faster then ritalin and adderall.