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Methylcobalamin- An Info Thread
#1

Methylcobalamin- An Info Thread

If you all weren't aware, the most bioavailable version of Vitamin B-12 is not the one which you usually take with your multivitamins. That is a different version called cyanocobalamin, which has much more difficulty binding to your red blood cells due to the fact that it has to be detoxified by the liver due to the fact that it has a cyanide molecule attached to it.

The solution here is not straight cobalamin, but methylcobalamin, as the methyl molecule makes it much more bioavailable.

Some benefits of methylcobalamin are repairing nerve tissue, increased mental focus, higher energy levels, and along those lines boosts metabolism of macronutrients.

The catch here is that they rarely (if ever) include it in the formulas for multi-vitamins, because it is quite hard to put it into a solid form that is dissolvable in the stomach. The best way to get methylcobalamin is definitely sublingually (under the tongue), as it goes directly into your bloodstream from your gums.

From my personal experience, B-12 in methylcobalamin form saved me from a mononucleosis induced hell. When I had developed mononucleosis, I began to take 5mg in the morning and lo and behold, I felt fine throughout the first half of the day. If I needed to go to the gym (against the docs wishes), I would just take another one.

Maybe it's because my mono wasn't terrible. Maybe it was because I kept myself relatively healthy. But I do believe, now that I'm not taking it, that it increased my energy levels to a point where I could be a normal human being on mono and have a bit more energy while healthy.

Also, don't buy pills for $50. Solgar sells some for $5 on ebay.
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#2

Methylcobalamin- An Info Thread

Quote: (02-13-2013 04:37 AM)Aer Wrote:  

If you all weren't aware, the most bioavailable version of Vitamin B-12 is not the one which you usually take with your multivitamins. That is a different version called cyanocobalamin, which has much more difficulty binding to your red blood cells due to the fact that it has to be detoxified by the liver due to the fact that it has a cyanide molecule attached to it.

The solution here is not straight cobalamin, but methylcobalamin, as the methyl molecule makes it much more bioavailable.

Your physiology is a bit off. The cyanide in the vitamin B12 molecule is trapped and harmless (in fact, the treatment of cyanide poisoning is to give a substance that converts cyanide into vitamin B12). The methylated B12 you take has to be converted into normal B12 by the body in order for it to be used.

As a side process, you will also generate methionine, an amino acid as a byproduct if you take methylated B12. This might explain some of the benefits you experience, as you were possibly triggering off a protein rush. Homocysteine will also drop, and some people are claiming that it is an inflammatory molecule, so less inflammation may result.

Although if the stuff works, who cares how it works? As long as it works all is good.

From wikipedia:
[Image: Folicacid-B12.png]
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#3

Methylcobalamin- An Info Thread

Quote: (02-13-2013 05:14 AM)Thomas the Rhymer Wrote:  

Quote: (02-13-2013 04:37 AM)Aer Wrote:  

If you all weren't aware, the most bioavailable version of Vitamin B-12 is not the one which you usually take with your multivitamins. That is a different version called cyanocobalamin, which has much more difficulty binding to your red blood cells due to the fact that it has to be detoxified by the liver due to the fact that it has a cyanide molecule attached to it.

The solution here is not straight cobalamin, but methylcobalamin, as the methyl molecule makes it much more bioavailable.

Your physiology is a bit off. The cyanide in the vitamin B12 molecule is trapped and harmless (in fact, the treatment of cyanide poisoning is to give a substance that converts cyanide into vitamin B12). The methylated B12 you take has to be converted into normal B12 by the body in order for it to be used.

As a side process, you will also generate methionine, an amino acid as a byproduct if you take methylated B12. This might explain some of the benefits you experience, as you were possibly triggering off a protein rush. Homocysteine will also drop, and some people are claiming that it is an inflammatory molecule, so less inflammation may result.

Although if the stuff works, who cares how it works? As long as it works all is good.

From wikipedia:
[Image: Folicacid-B12.png]

I apologize, I'm not a chemistry expert. But you're definitely right about the anti-inflammatory part, my enlarged spleen and liver definitely seemed to decrease in swelling after I took the pills, and it gave me enough energy to work out.

Maybe it's just my experience, I have no idea if anyone has ever taken this on mono before.

But aside from mono, I have to say that it works much better than the B-12 you get in most multis or B-Complex pills.
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#4

Methylcobalamin- An Info Thread

Thomas, is there any downside to taking 5mg methylcobalamin a day? That's a megadose, right?
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#5

Methylcobalamin- An Info Thread

Quote: (02-14-2013 07:06 AM)Acute Angle Wrote:  

Thomas, is there any downside to taking 5mg methylcobalamin a day? That's a megadose, right?

I can't find any safety data on the mega doses.

Some guys did pump 1 mg a day into alzheimer's patients to see what it would do (it didn't do much), and they gave it for 2 years without any adverse effects noted.

A study appeared to show a pain-killing activity for methylcobalamin at 0.75mg (750micrograms) daily. Maybe the active dose doesn't need to go all the way up to 5mg.

At this point it's very much a use at your own risk kind of drug.

Physiologically speaking, the main issue would be the effect of chronic vitamin B12 overload on your liver and you nervous tissue, and maybe development of reddish discolouration of your hands and feet due to methylcobalamin's red colour (kind of like beta-carotenemia due to beta-carotene or riboflavinemia) but that's just speculation on my part.

I just read up on its absorption and it is absorbed the same way as Vitamin B12, through the activity of Intrinsic Factor which you only get in the stomach. Without Intrinsic Factor, you will only absorb between 1 - 10% of what you take in if memory serves me right. So 5mg sublingually, in the absence of intrinsic factor, amounts to only 0.5mg absorbed at most anyway. Injections are the way to go if you really wanna go on megadoses, because then you don't have to bother with intrinsic factor as an absorption carrier.
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#6

Methylcobalamin- An Info Thread

Quote: (02-13-2013 05:14 AM)Thomas the Rhymer Wrote:  

Quote: (02-13-2013 04:37 AM)Aer Wrote:  

If you all weren't aware, the most bioavailable version of Vitamin B-12 is not the one which you usually take with your multivitamins. That is a different version called cyanocobalamin, which has much more difficulty binding to your red blood cells due to the fact that it has to be detoxified by the liver due to the fact that it has a cyanide molecule attached to it.

The solution here is not straight cobalamin, but methylcobalamin, as the methyl molecule makes it much more bioavailable.

Your physiology is a bit off. The cyanide in the vitamin B12 molecule is trapped and harmless (in fact, the treatment of cyanide poisoning is to give a substance that converts cyanide into vitamin B12). The methylated B12 you take has to be converted into normal B12 by the body in order for it to be used.

As a side process, you will also generate methionine, an amino acid as a byproduct if you take methylated B12. This might explain some of the benefits you experience, as you were possibly triggering off a protein rush. Homocysteine will also drop, and some people are claiming that it is an inflammatory molecule, so less inflammation may result.

Although if the stuff works, who cares how it works? As long as it works all is good.

From wikipedia:
[Image: Folicacid-B12.png]

Beat me to it.
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#7

Methylcobalamin- An Info Thread

I've purchased these as I've had a fucked up health problem which my doctor, dentist, physio or fucking any health professional can't help me with, the fucking mongs.

Don't forget to check out my latest post on Return of Kings - 6 Things Indian Guys Need To Understand About Game

Desi Casanova
The 3 Bromigos
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#8

Methylcobalamin- An Info Thread

My B12 level has been in the low 200's lately, so I'm looking to supplement and get above 400 pg/mL where my doctor recommends. His opinion is that only sublingual or injections actually work, but I'm finding different studies like the one below showing that even with 500mcg of the supposedly inferior cyanocobalamin, levels were significantly raised within 1 week with almost no difference between sublingual and tablet at 4 weeks. This study also appears to state that mega doses are unnecessary. Am I missing something here or is the store brand of 1000mcg of cyanocobalamin just as likely to restore B12 levels as compared to sublingual Methylcobalamin?

"In this prospective study of 30 subjects with vitamin B12 deficiency, we found that sublingual and oral administration of 500 µg of cobalamin was equally effective in correcting cobalamin concentrations. Most of the increase in cobalamin concentrations was achieved by the end of the first week of treatment (Figure 1). Previous studies used sublingual or oral doses of 1000–5000 µg [5–9]. Our study shows that as little as 500 µg is enough to correct cobalamin deficiency" (Sharabi, Amir , et al)
source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884303/

[Image: bcp0056-0635-f1.gif]

Regarding absorption, a 2014 study states "A common concern with oral VB12 therapy is absorption of the compound in the context of pernicious anemia or gastrointestinal disease or resection. While most dietary VB12 is absorbed actively via intrinsic factor, passive diffusion accounts for about 1% of VB12 absorption, with bioavailability unaffected in those with pernicious anemia or gastroduodenal surgical resection.15 Therefore, an oral dose of 1000 μg daily is more than sufficient to meet the Canadian recommended dietary allowance of 1.8 to 2.4 μg daily.18 Numerous studies have found oral therapy to be sufficient even in patients lacking intrinsic factor and those with gastrointestinal disease or bowel resections" (Michael R. Kolber Oral vitamin B12: a cost-effective alternative)
source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922551/
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#9

Methylcobalamin- An Info Thread

Quote: (07-27-2016 11:22 AM)TheThinker Wrote:  

My B12 level has been in the low 200's lately, so I'm looking to supplement and get above 400 pg/mL where my doctor recommends. His opinion is that only sublingual or injections actually work, but I'm finding different studies like the one below showing that even with 500mcg of the supposedly inferior cyanocobalamin, levels were significantly raised within 1 week with almost no difference between sublingual and tablet at 4 weeks.

Normal oral therapy is probably adequate, especially if you are not anaemic; but the injection is usually cheaper, at least where I work (South Africa). But I read that the body can only absorb 50mcg of vitamin B12 at a time, the rest is excreted in the urine, so the usual 1000mcg injection doses could possibly be useless.

I think the quality of the tablets you get is also an important factor.

I think there probably is not a 'better' option and it boils down to personal preference. The cheapest method to treat deficiency is to get a monthly B12 shot (although to start off with weekly shots can be used, or even daily with severe deficiency). If you don't like injections then take a daily oral dose, or maybe sublingual. I have no experience with sublingual B12 (they are not available in my country) so I can't comment on that particular dosing method.
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#10

Methylcobalamin- An Info Thread

Thank you for the reply. I'm going to break up the 1000mcg tablets into two doses to take with breakfast and lunch and try that for 4 weeks. Then I may get my levels checked again.
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