[TheMan]

These are some interesting findings based on research done into what makes for a good pick-up line.

Quote:

Mentally tired people are less receptive to clever pick-up lines. Innocuous pick-up lines work better in these instances. Direct pickup lines weren’t affected by mental exhaustion. (Hat tip: BPS)


The success of a relationship initiation strategy, such as a pick-up line or opening gambit, may depend on the target’s state receptivity.
Self-control is a limited resource that, when depleted, can potentially influence interpersonal interactions.
The present research examines whether ego depletion can influence receptivity to various types of opening gambits.
To accomplish this, 99 currently single participants either wrote a story with several restrictions (ego-depletion group) or wrote without restrictions (non-depletion group), and then read direct, innocuous, or cute opening gambits.
Following each type of gambit, participants rated their receptivity by indicating how likely they would be to continue to talk to the initiator, view the initiator positively, and give the initiator their phone number.
As predicted, analyses revealed that those who participated in the ego-depletion task were significantly less receptive to cute opening gambits and there was a trend of being more receptive to innocuous opening gambits, relative to the non-depletion group.
Ego depletion did not influence direct gambits.

the Source is “Pick me up: Ego depletion and receptivity to relationship initiation” from Journal of Social and Personal Relationships

[TXH]

So if a girl looks tired, don't be too clever. Sounds like basic calibration to me.

[Alpha Hunter Zero]

We should add some examples on here for each category as a quick reference guide for members.

[20Nation]

I don't think you should ever be too witty. Even though they do it in the movies, I think it comes off as try hard. It immediately sets the girls as the prize. Just do something simple. She probably won't even remember what you said to open her the next day.